Article

Structural determinants of mutability across cancer genomes

2019-01-01

Abstract excerpt

Cancer is a group of diseases which are characterised and actuated by somatic mutations. In cancer the distribution of mutations across the genome is inhomogeneous, with genomic and epigenomic features influencing mutational patterns. Previous studies have indicated that chromatin organization and replication time domains are correlated with and thus predictive of this variation. Here the role of alternative DNA s...

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Literature Corpus work: e42b166d-fe69-5f8f-b8f5-450ccb420de0
DOI: 10.17863/cam.38141

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