Article

A computational framework for detecting signatures of accelerated somatic evolution in cancer genomes

2017-08-16

Abstract excerpt

<h4>ABSTRACT</h4> By accumulation of somatic mutations, cancer genomes evolve, diverging away from the genome of the host. It remains unclear to what extent somatic evolutionary divergence is comparable across different regions of the cancer genome versus concentrated in specific genomic elements. We present a novel computational framework, SASE-mapper, to identify genomic regions that show signatures of accelera...

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Literature Corpus work: 5dbee001-382d-5d56-bfcc-6b3accebd805
DOI: 10.1101/177261

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