Article

APOBEC mutagenesis is low in most types of non-B DNA structures, unlike other types of cancer mutagenesis

2021-10-12

Abstract excerpt

While somatic mutations are known to be enriched in genome regions with non-canonical DNA secondary structure, the impact of particular mutagens still needs to be elucidated. Here, we demonstrate that in human cancers, the APOBEC mutagenesis is not enriched in direct repeats, mirror repeats, short tandem repeats, and G-quadruplexes, and even decreased below its level in B-DNA for cancer samples with very high APOB...

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Literature Corpus work: cd5c1b0a-b393-5c02-b554-a1630818d952
DOI: 10.1101/2021.10.12.464135

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