Article

Common germline polymorphisms and somatic cancer mutations exhibit non-random positional overlap across the human genome

2026-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Germline and somatic mutations have traditionally been studied independently because they arise in distinct biological contexts and are shaped by different selective pressures. Despite these differences, both originate from the same molecular processes of DNA damage, replication error, and DNA repair. Yet this separation has limited the opportunity of investigation of genomic loci recurrently mu...

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Literature Corpus work: 2e316ba5-677c-5e16-b5f3-bd4aa6c62c99
DOI: 10.64898/2026.08.03.742387

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