Article

Diversity and Genomic Organization of Non-B DNA Motifs in Haplotype-Resolved Human Genome Assemblies

2026-03-07

Abstract excerpt

Long-read sequencing and telomere-to-telomere genome assemblies now enable the exploration of previously inaccessible repetitive and structurally complex regions of the human genome. Using 130 haplotype-resolved genome assemblies from 65 individuals across diverse populations, we systematically analyzed six major classes of non-B DNA motifs. By evaluating their biophysical stability, we distinguished structurally...

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Literature Corpus work: 55691e3a-ef70-5a7d-bc7a-c3eb82f526ad
DOI: 10.64898/2026.03.05.709836

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