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Article

Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes.

Genome biology - 3 May 2021

Lee Christian A, Abd-Rabbo Diala, Reimand Jüri

Abstract excerpt

BACKGROUND: Cancer genomes are shaped by mutational processes with complex spatial variation at multiple scales. Entire classes of regulatory elements are affected by local variations in mutation frequency. However, the underlying mechanisms with functional and genetic determinants remain poorly understood. RESULTS: We characterise the mutational landscape of 1.3 million gene-regulatory and chromatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33941236
DOI: 10.1186/s13059-021-02318-x
PMCID: PMC8091793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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