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Article

Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.

Nucleic acids research - 22 Feb 2021

Guiblet Wilfried M, Cremona Marzia A, Harris Robert S, Chen Di, Eckert Kristin A, Chiaromonte Francesca, Huang Yi-Fei, Makova Kateryna D

Abstract excerpt

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication, increasing errors and facilitating mutagenesis, yet its contribution to genome-wide variation in mutation rates remains unexplored. Here, we conducted a comprehensive analysis of nucleotide...

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Identifiers

PMID: 33450015
DOI: 10.1093/nar/gkaa1269
PMCID: PMC7897504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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