Article
Tumor mutational landscape is a record of the pre-malignant state
2019-01-11
Abstract excerpt
<h4>ABSTRACT</h4> Chromatin structure has a major influence on the cell-specific density of somatic mutations along the cancer genome. Here, we present a pan-cancer study in which we searched for the putative cancer cell-of-origin of 2,550 whole genomes, representing 32 cancer types by matching their mutational landscape to the regional patterns of chromatin modifications ascertained in 104 normal tissue types. W...
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Identifiers and source
- Literature Corpus work
- 3ecb7b28-c5aa-5206-9265-5e869e9dc8a9
- DOI
- 10.1101/517565