Article

Impact of cancer mutational signatures on transcription factor motifs in the human genome

2018-09-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Somatic mutations in cancer genomes occur through a variety of molecular mechanisms, which contribute to different mutational patterns. To summarize these, mutational signatures have been defined using a large number of cancer genomes, and related to distinct mutagenic processes. Each cancer genome can be compared to this reference dataset and its exposure to one or the othe...

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Literature Corpus work: 146432fb-d6d8-56c5-a528-b32054f651c1
DOI: 10.1101/422386

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