Article
Non-B DNA structures and their contributions to genetic diversity, aging, and disease.
Nucleic acids research - 5 Feb 2026
Bochalis Eleftherios, Dereki Irene, Wang Guliang, Sgourou Argyro, Vasquez Karen M, Georgakopoulos-Soares Ilias
Abstract excerpt
DNA is most often found in its canonical B-form double-helical structure, but can also adopt alternative conformations, known as non-B DNA structures. Numerous non-B structures have been characterized, including G-quadruplexes, i-motifs, Z-DNA, hairpins, cruciforms, slipped structures, R-loops, and H-DNA. Non-B DNA motifs are enriched in functional regions, including near transcription start and end sites,...
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