Article

Tau Conformers in FTLD-MAPT  Undergo Liquid-liquid Phase Separation and Perturb the Nuclear Envelope

2020-09-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Germline mutations in the <italic>MAPT</italic> gene cause some forms of frontotemporal lobar degeneration (FTLD). Recent studies show that a single mutation in <italic>MAPT</italic> can promote alternative tau misfolding pathways engendering divergent tau conforms and representing clinical heterogeneity, and that under conditions of cell-free molecular crowding...

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Literature Corpus work: 8584113d-66a6-5fb2-8408-c4bd2bb956b6
DOI: 10.21203/rs.3.rs-81447/v1

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