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Article

Tau liquid-liquid phase separation in neurodegenerative diseases.

Trends in cell biology - 1 Jul 2022

Boyko Solomiia, Surewicz Witold K

Abstract excerpt

Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several other neurodegenerative disorders. An exciting recent development is the finding that, akin to some other proteins associated with neurodegenerative disease, tau has a high propensity to condensate via the mechanism of liquid-liquid phase separation (LLPS). Here, we discuss the evidence for tau LLPS in...

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Identifiers

PMID: 35181198
DOI: 10.1016/j.tcb.2022.01.011
PMCID: PMC9189016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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