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RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration

25 Oct 2018

Abstract excerpt

Frontotemporal dementia is a group of early onset dementia syndromes linked to underlying frontotemporal lobar degeneration (FTLD) pathology that can be classified based on the formation of abnormal protein aggregates involving tau and two RNA binding proteins, TDP-43 and FUS. Although elucidation of the mechanisms leading to FTLD pathology is in progress, recent advances in genetics and neuropathology indicate...

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PMID: 30355151
DOI: 10.1146/annurev-pathmechdis-012418-012955

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