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Article

Liquid-liquid phase separation induces pathogenic tau conformations in vitro.

Nature communications - 4 Jun 2020

Kanaan Nicholas M, Hamel Chelsey, Grabinski Tessa, Combs Benjamin

Abstract excerpt

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells meet the biological requirement for spatiotemporal regulation of cellular components and reactions. Recently, tau, a protein known for its involvement in Alzheimer's disease and other tauopathies, was found to undergo liquid-liquid phase separation making it one of several proteins associated with neurodegenerative diseases...

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Identifiers

PMID: 32499559
DOI: 10.1038/s41467-020-16580-3
PMCID: PMC7272632

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