Article

Abnormal microtubule dynamics disrupt nucleocytoplasmic transport in tau-mediated frontotemporal dementia

2018-05-22

Abstract excerpt

<h4>SUMMARY</h4> The neuronal microtubule-associated protein tau ( MAPT ) is central to the pathogenesis of many dementias, including Alzheimer’s disease. Autosomal dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic mechanisms are unclear. Using human stem cell models of FTD due to MAPT mutations, we find that tau becomes hyperphosphorylated and mislocalises...

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Literature Corpus work: d98e3068-9907-59f1-a334-93924bab6f9f
DOI: 10.1101/328187

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