Article

Tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and perturb the nuclear envelope

2020-07-05

Abstract excerpt

Recent studies show that a single MAPT gene mutation can promote alternative tau misfolding pathways engendering divergent forms of frontotemporal dementia and that under conditions of molecular crowding, the repertoire of tau forms can include liquid-liquid phase separation (LLPS). We show here that following pathogenic seeding, tau condenses on the nuclear envelope (NE) and disrupts nuclear-cytoplasmic transpor...

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Literature Corpus work: f738b537-bcce-58db-9a4a-48df8a626806
DOI: 10.1101/2020.07.04.187997

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