Article

Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease

2025-05-23

Abstract excerpt

<h4>ABSTRACT</h4> The microtubule-associated protein tau aggregates into oligomeric complexes that highly correlate with Alzheimer’s disease (AD) progression. Increasing evidence suggests that nuclear membrane disruption occurs in AD and related tauopathies, but whether this is a cause or consequence of neurodegeneration remains unclear. Using the optogenetically inducible 4R1N Tau::mCherry::Cry2Olig (optoTau) sy...

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Literature Corpus work: fc7491c3-3951-5916-925e-bda66e2076ce
DOI: 10.1101/2025.05.21.655370

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