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Disrupting pathologic phase transitions in neurodegeneration

2 Jul 2023

Abstract excerpt

Solid-like protein deposits found in aged and diseased human brains have revealed a relationship between insoluble protein accumulations and the resulting deficits in neurologic function. Clinically diverse neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis, exhibit unique and disease-specific biochemical protein...

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PMID: 37395272
DOI: 10.1172/jci168549

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