Article

Distinct tau filament folds in familial frontotemporal dementia due to the <i>MAPT</i> S305I mutation

2026-02-14

Abstract excerpt

Frontotemporal lobar degeneration with tau inclusions (FTLD-tau) comprise a class of fatal heterogeneous neurodegenerative diseases. Approximately 10% arise from pathogenic MAPT mutations and often cause severe, early-onset disease with pathology that is distinct yet partially overlapping with sporadic cases. Here, we evaluated post-mortem tissue from a patient with FTLD-tau due to MAPT S305I showing neuropatholo...

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Literature Corpus work: 0e0289d0-9044-5006-8d36-b60b0cb02b92
DOI: 10.64898/2026.02.12.705620

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