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Article

Pathological phase transitions in ALS-FTD impair dynamic RNA-protein granules.

RNA (New York, N.Y.) - 1 Jan 2022

Nedelsky Natalia B, Taylor J Paul

Abstract excerpt

The genetics of human disease serves as a robust and unbiased source of insight into human biology, both revealing fundamental cellular processes and exposing the vulnerabilities associated with their dysfunction. Over the last decade, the genetics of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have epitomized this concept, as studies of ALS-FTD-causing mutations have yielded fundamental...

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Identifiers

PMID: 34706979
DOI: 10.1261/rna.079001.121
PMCID: PMC8675280

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