Article

Post-Translational Modifications Control Phase Transitions of Tau

2024-03-12

Abstract excerpt

<h4>ABSTRACT</h4> The self-assembly of Tau(297-391) into filaments, which mirror the structures observed in Alzheimer’s disease (AD) brains, raises questions about the role of AD-specific post-translational modifications (PTMs) in the formation of paired helical filaments (PHFs). To investigate this, we developed a synthetic approach to produce Tau(291-391) featuring N-acetyllysine, phosphoserine, phosphotyrosine...

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Literature Corpus work: 6879d939-2699-5403-8b76-ccb0220b456a
DOI: 10.1101/2024.03.08.583040

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