Article

Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion

2022-09-03

Abstract excerpt

Reducing the level of microtubule-associated protein tau has recently emerged as a promising therapeutic approach for a range of neurodegenerative diseases. Among the various approaches, targeted protein degradation provides a reversible means to rapidly reduce and specifically target disease-relevant forms of tau. However, in aging cells, the protein turnover activity is generally weakened, reducing the efficacy...

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Literature Corpus work: 818c5e8f-7cd6-504d-881e-5ed4cb85c532
DOI: 10.1101/2022.09.01.506229

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