Article

Targeted protein degradation using degradFP in <i>Trypanosoma brucei</i>

2022-06-02

Abstract excerpt

Targeted protein degradation is an invaluable tool in studying the function of proteins. Such a tool was not available in Trypanosoma brucei , an evolutionarily divergent eukaryote that causes human African trypanosomiasis. Here, we have adapted degradFP (degrade Green Fluorescent Protein), a protein degradation system based on the SCF E3 ubiquitin ligase complex and anti-GFP nanobody, in T. brucei . As a proof...

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Literature Corpus work: 59477e92-538e-5eba-9c1a-0a2cba84c734
DOI: 10.1101/2022.06.01.494430

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