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Article

PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins.

The Journal of cell biology - 3 Jul 2006

Janer Alexandre, Martin Elodie, Muriel Marie-Paule, Latouche Morwena, Fujigasaki Hiroto, Ruberg Merle, Brice Alexis, Trottier Yvon, Sittler Annie

Abstract excerpt

The pathogenesis of spinocerebellar ataxia type 7 and other neurodegenerative polyglutamine (polyQ) disorders correlates with the aberrant accumulation of toxic polyQ-expanded proteins in the nucleus. Promyelocytic leukemia protein (PML) nuclear bodies are often present in polyQ aggregates, but their relation to pathogenesis is unclear. We show that expression of PML isoform IV leads to the formation of distinct...

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Identifiers

PMID: 16818720
DOI: 10.1083/jcb.200511045
PMCID: PMC2064165

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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