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Article

The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation.

Nature cell biology - 1 Aug 2024

Zhou Jiechao, Chuang Yang 'an, Redding-Ochoa Javier, Zhang Rongzhen, Platero Alexander J, Barrett Alexander H, Troncoso Juan C, Worley Paul F, Zhang Wenchi

Abstract excerpt

Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3 ligase, TRIAD3A, that functions as an autophagy adaptor for tau. TRIAD3A(RNF216) is an essential gene with mutations causing age-progressive neurodegeneration. Our studies reveal that TRIAD3A E3 ligase catalyses mixed K11/K63 polyubiquitin chains and self-assembles...

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Identifiers

PMID: 39009640
DOI: 10.1038/s41556-024-01461-4
PMCID: PMC11921440

Genes

RNF216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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