Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.

The Journal of biological chemistry - 1 Dec 2022

Li Tianyou, Yin Limin, Kang Xinyi, Xue Wenlong, Wang Ning, Zhang Jie, Yuan Ping, Lin Lingxi, Li Yang

Abstract excerpt

Lysosomes are one of the major centers for regulating cargo degradation and protein quality control. Transcription factor EB (TFEB)-promoted lysosome biogenesis enhances lysosome-mediated degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB modification and activation are still poorly understood. Here, we report essential roles of TFEB acetylation in TFEB nuclear translocation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Autophagy

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Share to Lysosomes

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 36441024
DOI: 10.1016/j.jbc.2022.102649
PMCID: PMC9694136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.PMID 36441024Read ↗

Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s DiseaseSemantic proximity Read ↗

TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implicationsSemantic proximity Read ↗

TFEB; Beyond Its Role as an Autophagy and Lysosomes RegulatorSemantic proximity Read ↗

From the regulatory mechanism of TFEB to its therapeutic implicationsSemantic proximity Read ↗

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EBSemantic proximity Read ↗

TFEB Biology and Agonists at a GlanceSemantic proximity Read ↗

Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated AutophagySemantic proximity Read ↗

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neuronsSemantic proximity Read ↗

The regulatory mechanism and therapeutic potential of transcription factor <scp>EB</scp> in neurodegenerative diseasesSemantic proximity Read ↗

The Role and Regulatory Mechanism of Transcription Factor EB in Health and DiseasesSemantic proximity Read ↗

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesisSemantic proximity Read ↗

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascadeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.