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Article

SPOP loss of function protects against tauopathy

27 Dec 2022

Abstract excerpt

The pathological accumulation of the microtubule binding protein tau drives age-related neurodegeneration in a variety of disorders, collectively called tauopathies. In the most common tauopathy, Alzheimer’s disease (AD), the accumulation of pathological tau strongly correlates with cognitive decline. The underlying molecular mechanisms that drive neurodegeneration in tauopathies remain incompletely understood...

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PMID: 36574656
DOI: 10.1073/pnas.2207250120

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