Article

Examining the potential involvement of NONO in TDP-43 proteinopathy in Drosophila

2024-10-20

Abstract excerpt

The misfolding and aggregation of TAR DNA binding protein-43 (TDP-43), leading to the formation of cytoplasmic inclusions, emerge as a key pathological feature in a spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). TDP-43 shuttles between the nucleus and cytoplasm but forms nuclear bodies (NBs) in response to stress. These NBs partially...

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Literature Corpus work: 90d3e27e-d586-5859-8d4c-a3cac25a5dde
DOI: 10.22541/au.172945325.57047516/v1

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