Article

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein Tau

2024-06-10

Abstract excerpt

RING-H2 type E3 ligase Praja family is composed of Praja1 and Praja2, which promote the degradation of substrates through the ubiquitin-proteasome system. Both paralogs contribute to neuronal maturation and differentiation, indicating a significant role in the nervous system. Aggregation-prone proteins associated with neurodegenerative diseases, including TDP-43 and α-synuclein, are degraded and/or suppressed by P...

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Literature Corpus work: f66be892-7a04-5edd-ac4a-2899c6e09630
DOI: 10.1101/2024.06.10.598176

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