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Article

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.

Molecular cell - 2 Jul 2004

Schaffar Gregor, Breuer Peter, Boteva Raina, Behrends Christian, Tzvetkov Nikolay, Strippel Nadine, Sakahira Hideki, Siegers Katja, Hayer-Hartl Manajit, Hartl F Ulrich

Abstract excerpt

The expression of polyglutamine-expanded mutant proteins in Huntington's disease and other neurodegenerative disorders is associated with the formation of intraneural inclusions. These aggregates could potentially cause cellular toxicity by sequestering essential proteins possessing normal polyQ repeats, including the transcription factors TBP and CBP. We show, in vitro and in cells, that monomers or small...

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Source

Identifiers

PMID: 15225551
DOI: 10.1016/j.molcel.2004.06.029

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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