Article

Nanobodies targeting hnRNPA2/B1 and tau

2025-11-24

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is an RNA-binding protein that mislocalizes to the cytoplasm and forms stress-induced granules in tauopathy and multisystem proteinopathy. It also preferentially interacts with oligomeric tau and is required for tau-mediated neurodegeneration in a mouse model of Alzheimer’s disease. To study endogenous hnRNPA2/B1 and tau, we generated nanobodies that speci...

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Identifiers and source

Literature Corpus work: c2025432-bc62-5a06-8a88-f4a27262492b
DOI: 10.1101/2025.11.21.689763

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