Article

Examining the potential involvement of NONO in TDP-43 proteinopathy in <i>Drosophila</i>

2023-12-13

Abstract excerpt

The misfolding and aggregation of TAR DNA binding protein-43 (TDP-43), leading to the formation of cytoplasmic inclusions, emerge as a key pathological feature in a spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). TDP-43 shuttles between the nucleus and cytoplasm but forms nuclear bodies (NBs) in response to stress. These NBs partially...

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Literature Corpus work: a18c018b-be3c-51a1-9231-f27d7c6dc18c
DOI: 10.1101/2023.12.13.571416

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