Article

Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies

2025-01-22

Abstract excerpt

In Alzheimer’s disease (AD) and other tauopathies, tau dissociates from microtubules and forms toxic aggregates that contribute to neurodegeneration. Although some of the pathological interactions of tau have been identified from postmortem brain tissue, these studies are limited by their inability to capture transient interactions. To investigate the interactome of aggregate-prone fragments of tau, we applied an...

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Literature Corpus work: 10c589f7-e8f0-5097-91e6-aeb6bc4944fb
DOI: 10.1101/2025.01.22.633945

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