Article

Protein degradation by small tag artificial bacterial E3 ligase

2024-09-07

Abstract excerpt

<h4>ABSTRACT</h4> Targeting of proteins for degradation in a reversible manner is a powerful approach to decipher gene function and mimic drug effects, with great potential for drug target discovery and validation. A generalized approach is to tag a protein of interest and then use this tag to recruit an endogenously or exogenously expressed E3 ligase for its polyubiquitination and subsequent degradation via 26S...

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Literature Corpus work: 151a47ed-8d57-5744-8641-b0cbb8674ec9
DOI: 10.1101/2024.09.07.611797

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