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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia.

Translational psychiatry - 22 Sept 2021

Kalinowski Agnieszka, Liliental Joanna, Anker Lauren A, Linkovski Omer, Culbertson Collin, Hall Jacob N, Pattni Reenal, Sabatti Chiara, Noordsy Douglas, Hallmayer Joachim F, Mellins Elizabeth D, Ballon Jacob S, O'Hara Ruth, Levinson Douglas F, Urban Alexander E

Abstract excerpt

Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression. C4-anaphylatoxin (C4-ana) is a C4 protein fragment released upon C4 protein activation that has the potential to change the blood-brain barrier (BBB). We hypothesized that elevated plasma levels of C4-ana occur in...

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Identifiers

PMID: 34552056
DOI: 10.1038/s41398-021-01583-5
PMCID: PMC8458380

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