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Article

Excess GDNF associates with a subtype of schizophrenia with enhanced dopamine and increased prefrontal dysfunction

2025-08-16

Abstract excerpt

Schizophrenia (SCZ) displays a heterogeneous etiology. In about half of the patients, first-episode psychosis (FEP) associates with increased levels of striatal dopamine (DA), while cognitive and negative symptoms associate with reduced DA function in the prefrontal cortex (PFC). However, the mechanism underlying these changes in DA is unclear. Abnormal increase in glial cell-line derived neurotrophic factor (GDNF...

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Literature Corpus work
dcaeaf93-9892-51a9-be60-7d039c436477
DOI
10.1101/2025.08.11.25333355
Open publication

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Excess GDNF associates with a subtype of schizophrenia with enhanced dopamine and increased prefrontal dysfunctionDOI 10.1101/2025.08.11.25333355
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