Article

Cerebrospinal fluid proteomics reveals synaptic and immune dysregulation in treatment-resistant schizophrenia

2025-05-15

Abstract excerpt

<h4>IMPORTANCE</h4> Treatment-resistant schizophrenia (TRS) affects around one-third of individuals with schizophrenia and is associated with substantial morbidity, mortality, and healthcare burden. Despite its impact, the pathophysiology of TRS remains poorly understood, and no validated biomarkers exist to predict or stratify treatment resistance and identify patients who may benefit from earlier second-line in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa2166bb-1420-55b3-83e6-577af5aefb56
DOI: 10.1101/2025.05.14.25327624

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebrospinal fluid proteomics reveals synaptic and immune dysregulation in treatment-resistant schizophreniaDOI 10.1101/2025.05.14.25327624Read

Cerebrospinal fluid biomarkers reveal transdiagnostic synaptic dysfunction across major psychiatric disordersSemantic proximity Read

Application of Proteomic Techniques for Improved Stratification and Treatment of Schizophrenia Patients.Semantic proximity Read

Revealing potential drug targets in schizophrenia through proteome-wide Mendelian randomization genetic insights.Semantic proximity Read

The Multiomics Landscape of Plasma Exosomes in First-Episode Drug-Naïve of SchizophreniaSemantic proximity Read

Circulating Blood-Based Proteins in Psychopathology and CognitionSemantic proximity Read

Pathway-Phenotypes of Non-responders and Partial Responders to Treatment With Antipsychotics in Schizophrenia: A Machine Learning StudySemantic proximity Read

Application and integration of bioinformatic strategies towards central and peripheral proteomic profiling for diagnosis and drug discovery in schizophreniaSemantic proximity Read

Autoimmune phenotypes in schizophrenia reveal novel treatment targets.Semantic proximity Read

An Update on Promising Biomarkers in SchizophreniaSemantic proximity Read

Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectivesSemantic proximity Read

Large-Scale Mendelian Randomization Study Reveals Circulating Blood-based Proteomic Biomarkers for Psychopathology and Cognitive Task PerformanceSemantic proximity Read

Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar disorderSemantic proximity Read