Article
Schizophrenia risk from complex variation of complement component 4.
Nature - 11 Feb 2016
Sekar Aswin, Bialas Allison R, de Rivera Heather, Davis Avery, Hammond Timothy R, Kamitaki Nolan, Tooley Katherine, Presumey Jessy, Baum Matthew, Van Doren Vanessa, Genovese Giulio, Rose Samuel A, Handsaker Robert E, Daly Mark J, Carroll Michael C, Stevens Beth, McCarroll Steven A
Abstract excerpt
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the...
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