Article

Peripheral Complement C4 Protein in Schizophrenia: Association with Gene Copy Number and Immune Cell Subtypes

2025-09-17

Abstract excerpt

The lack of disease-modifying treatments for schizophrenia necessitates the exploration of novel aspects of its pathophysiology, including innate immune mechanisms in the periphery. C4 protein activation, associated with the complement cascade of innate immunity, associates with symptoms and predicts outcomes. However, C4 protein activation does not coincide with expected changes to other proteins in the complemen...

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Literature Corpus work: 04765905-7017-50f3-b3ae-c0437b464996
DOI: 10.1101/2025.09.16.676439

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