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Article

Cerebrospinal fluid biomarkers reveal transdiagnostic synaptic dysfunction across major psychiatric disorders

2025-10-30

Abstract excerpt

<title>Abstract</title> <p>Synaptic dysfunction is increasingly recognized as a core feature of psychiatric disorders, yet fluid biomarkers that reflect such changes in vivo are lacking. Here, we applied targeted mass spectrometry to quantify low-abundant synaptic proteins in cerebrospinal fluid from 672 individuals with anorexia nervosa, attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), sch...

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Literature Corpus work
c177b14c-7f2b-5edb-8e5f-1380a1abc35c
DOI
10.21203/rs.3.rs-7924300/v1
Open publication

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Cerebrospinal fluid biomarkers reveal transdiagnostic synaptic dysfunction across major psychiatric disordersDOI 10.21203/rs.3.rs-7924300/v1
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