Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

1 Jan 2014

Abstract excerpt

Understanding the formation and propagation of aggregates of the Alzheimer disease-associated Tau protein in vivo is vital for the development of therapeutics for this devastating disorder. Using our recently developed live-cell aggregation sensor in neuron-like cells, we demonstrate that different variants of exogenous monomeric Tau, namely full-length Tau (hTau40) and the Tau-derived construct K18 comprising...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Neuroimaging Techniques and Applications
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24235150
DOI: 10.1074/jbc.m113.515445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein PathologyPMID 24235150Read ↗

Fate and propagation of endogenously formed Tau aggregates in neuronal cellsSemantic proximity Read ↗

Tau in the brain interstitial fluid is fragmented and seeding–competentSemantic proximity Read ↗

Cellular and pathological heterogeneity of primary tauopathies.Semantic proximity Read ↗

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextSemantic proximity Read ↗

Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseasesSemantic proximity Read ↗

Sensitive detection and propagation of brain-derived tau assemblies in HEK293 based wild-type tau seeding assaysSemantic proximity Read ↗

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.Semantic proximity Read ↗

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of TauopathySemantic proximity Read ↗

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesiclesSemantic proximity Read ↗

Tau and neurodegeneration.Semantic proximity Read ↗

Mechanistic studies unravel the complexity inherent in tau aggregation leading to Alzheimer's disease and the tauopathies.Semantic proximity Read ↗

Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.