Article

Serine determines tissue targeted efficacy of PKM2 modulators in atopic dermatitis

2026-07-25

Abstract excerpt

<title>Abstract</title> <p>Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme that regulates immune cell activation, and PKM2 activators such as the literature tool compound, TEPP-46, have shown that targeting PKM2 is immunomodulatory. However, previous studies reveal a disconnect between TEPP-46 potency in cellular assays and efficacy in animal models of inflammation or autoimmunity. This study identifies seri...

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Literature Corpus work: 7e43017b-3a0d-50ad-96ac-7e2aed8027d4
DOI: 10.21203/rs.3.rs-9496359/v1

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