Article

Novel in-silico predicted matrikines are differential mediators of in vitro and in vivo cellular metabolism

2023-03-19

Abstract excerpt

<h4>Summary</h4> The exogenous application of small peptides can beneficially affect clinical skin appearance (wrinkles) and architecture (collagen and elastic fibre deposition and epidermal thickness). However, the discovery of new bioactive peptides has not been underpinned by any guiding hypothesis. As endogenous extracellular matrix (ECM)-derived peptides produced during tissue remodelling can act as molecula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8ad7606-1328-5998-ba77-a59c3cde91f4
DOI: 10.1101/2023.03.17.533127

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel in-silico predicted matrikines are differential mediators of in vitro and in vivo cellular metabolismDOI 10.1101/2023.03.17.533127Read

Bioactive tetrapeptide GEKG boosts extracellular matrix formation: <i>in vitro</i> and <i>in vivo</i> molecular and clinical proofSemantic proximity Read

Discovery of potent oligopeptides for various metabolic diseases using deep learningSemantic proximity Read

Single cell landscape of hypertrophic scars identifies serine proteases as key regulators of myofibroblast differentiationSemantic proximity Read

The Impact of Mechanical Cues on the Metabolomic and Transcriptomic Profiles of Human Dermal Fibroblasts Cultured in Ultrashort Self-Assembling Peptide 3D ScaffoldsSemantic proximity Read

Matrikines in kidney ageing and age-related diseaseSemantic proximity Read

Multi-omics analysis of keratinocytes reveals dermokine-dependent regulation of cell-cell adhesion via p120Semantic proximity Read

Single cell sequencing identifies serine proteases as regulators of myofibroblast differentiationSemantic proximity Read

Next-Generation Collagen: Innovations in Biosynthesis, Plant-Based Strategies, and Precision FermentationSemantic proximity Read

A designer mixture of six amino acids promotes the extracellular matrix gene expression in cultured human fibroblastsSemantic proximity Read

Endotrophin, a Key Marker and Driver for Fibroinflammatory DiseaseSemantic proximity Read

Metabolic Repression of Autophagy Drives Inflammation, Pain, and Malodor in Hidradenitis SuppurativaSemantic proximity Read

Metabolomic Profiling Reveals That 5-Hydroxylysine and 1-Methylnicotinamide Are Metabolic Indicators of Keloid SeveritySemantic proximity Read