Article

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

2019-11-26

Abstract excerpt

<h4>ABSTRACT</h4> The IκB kinase ε (IKKε) is a key molecule at the crossroads of inflammation and cancer. Known for its role as an activator of NFκB and IRF3 signalling leading to cytokine secretion, the kinase is also a breast cancer oncogene, overexpressed in a variety of tumours. However, to what extent IKKε remodels cellular metabolism is currently unknown. Here we used a combination of metabolomics and phosp...

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Literature Corpus work: f25cc743-9884-5800-b2c0-ca02f873a3aa
DOI: 10.1101/855361

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