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Pyruvate Kinase Isoenzyme M2 Impairs Cognition in Systemic Lupus Erythematosus by Promoting Microglial Synaptic Pruning via β-Catenin Signaling Pathway

2020-12-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Neuropsychiatric systemic lupus erythematosus (NPSLE) is the severest complication of SLE, which often involves pathological damage to the brain and cognitive function. Glucose metabolic changes are observed in SLE patients with cognitive impairments by medical imaging. Pyruvate kinase isoform M2 (PKM2) is a vital catalyzer of glucose catabolic pathways and in ne...

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Literature Corpus work: ab911fb3-0ce1-5564-ba4c-021b9cca9b24
DOI: 10.21203/rs.3.rs-126756/v1

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