Article

Targeting serine dehydratase supports amino acid homeostasis and skin repair

2025-10-24

Abstract excerpt

<h4>Summary</h4> Serine and glycine are altered in patients with metabolic disorders, and this dysregulation can lead to diverse pathologies 1–6 . Modulation of serine levels via diet can influence relevant phenotypes in mouse models of metabolic syndrome 7,8 . Here we identify serine dehydratase (Sds), a gluconeogenic hepatic enzyme involved in serine and threonine catabolism, as a key regulator of systemic se...

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Literature Corpus work: cf878f62-2b06-5bc3-9d75-8ade3d4797b3
DOI: 10.1101/2025.10.23.683531

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