Article

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

2021-12-23

Abstract excerpt

<h4>Summary</h4> Lung cancer is the leading cause of cancer-related death. Intriguingly, males with non-small cell lung cancer (NSCLC), the most common type of lung cancer, have a higher mortality rate than females. Here, we investigated the role of serine metabolism as a predictive marker for sensitivity to the antifolate pemetrexed in male and female NSCLC cell lines. Using [ 13 C 6 ] glucose tracing in NSCLC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1dd48eae-b036-5c5f-b5ce-eecdf022fa8c
DOI: 10.1101/2021.12.22.473923

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell linesDOI 10.1101/2021.12.22.473923Read

Probing Folate-Responsive and Stage-Sensitive Metabolomics and Transcriptional Co-Expression Network Markers to Predict Prognosis of Non-Small Cell Lung Cancer PatientsSemantic proximity Read

Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer MetastasisSemantic proximity Read

Shining a light on metabolic vulnerabilities in non-small cell lung cancer.Semantic proximity Read

Metabolic Diversity in Human Non-Small Cell Lung Cancer CellsSemantic proximity Read

Linking Serine/Glycine Metabolism to Radiotherapy ResistanceSemantic proximity Read

Multifaceted role of serine hydroxymethyltransferase in health and diseaseSemantic proximity Read

Multi-omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinomaSemantic proximity Read

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.Semantic proximity Read

Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma.Semantic proximity Read

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancerSemantic proximity Read

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer.Semantic proximity Read

Lineage-Specific Silencing of <i>PSAT1</i> Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast TumorsSemantic proximity Read