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Article

Extracellular serine availability regulates inflammatory skin phenotypes.

Biology direct - 28 May 2026

Sergio Simone, Montella Alessandro, Mancini Mara, Lena Anna Maria, Montanaro Manuela, Melino Gerry, Mauriello Alessandro, Candi Eleonora

Abstract excerpt

Serine has recently emerged as an important regulator of epidermal cell growth and skin repair, and modulation of serine metabolism through inhibition of Serine Hydroxy-Methyl Transferases (SHMTs) is already known to attenuate the development of skin inflammatory features in vivo. However, the contribution of serine/glycine free diet to inflammatory skin phenotypes, including psoriasis, has not yet been explored....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42210307
DOI: 10.1186/s13062-026-00825-0
PMCID: PMC13404384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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