Article

KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation

2025-10-14

Abstract excerpt

Inflammatory monocytes are increasingly recognized as key amplifiers of psoriasis, yet the epigenetic drivers of their pathogenic signature remain unclear. Here, we demonstrate that the histone demethylase KDM6B is markedly upregulated and catalytically active in classical monocytes during the imiquimod (IMQ)-induced psoriasis model. This is associated with reduced levels of the repressive histone mark H3K27me3, a...

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Literature Corpus work: a6e61006-a5cb-5cd5-ac43-d7688ca8dae4
DOI: 10.1101/2025.10.13.682023

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