Article

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions

2022-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Intracellular inclusions accompanying neurodegeneration are histopathologically and ultrastructurally heterogeneous but the significance of this heterogeneity is unclear. iPSC models, while promising for disease modeling, do not form inclusions in a reasonable timeframe and suffer from limited tractability. Here, we developed an iPSC toolbox utilizing piggyBac-based or targeted transgenes to rap...

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Literature Corpus work: efd76b29-b504-539b-9bda-b072b72e5478
DOI: 10.1101/2022.11.08.515615

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